Intrarenal Renin Angiotensin System Revisited
نویسندگان
چکیده
منابع مشابه
Intrarenal Renin-Angiotensin System Mediates Fatty
Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen 8 University, Guangzhou, China 510080 9 Department of Orthopedics, The 5 Affiliated Hospital, Sun Yat-sen University, 10 Zhuhai, China 519000 11 Department of Medicine, Division of Hypertension and Renal Diseases, 12 University of Colorado Denver, Aurora, CO, USA 80010 13 Department of Medicine, Division of Renal Diseases and ...
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Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
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Recent interest focuses on urinary renin and angiotensinogen as markers of renal renin-angiotensin system activity. Before concluding that these components are independent markers, we need to exclude that their presence in urine, like that of albumin (a protein of comparable size), is due to (disturbed) glomerular filtration. This review critically discusses their filtration, reabsorption and l...
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BACKGROUND We recently reported that immunoreactivity of intrarenal angiotensinogen (AGT) is significantly increased in IgA nephropathy patients. Meanwhile, we have developed direct enzyme-linked immunosorbent assays to measure plasma and urinary AGT (UAGT) in humans. This study was performed to test the hypothesis that UAGT levels are increased in chronic glomerulonephritis patients. METHODS...
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BACKGROUND The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. METHODS AND RESULTS A panel of mouse models including mice lacking angiotensinogen, Agt (Agt-KO), mice expressing Agt solely in adipose tissue (aP2-Agt/Agt-KO), and mice overexpressing Agt in adipose tissue (aP2-Agt) w...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.150284